Huang Shengyou

Doctor Huang received his bachelor's degree in Material Physics and his Ph.D. degree in Computational Soft Matter Physics from Wuhan University, Wuhan, China, in 2003. He is now a full professor in the School of Physics at Huazhong University of Science and Technology (HUST), Wuhan, China. Before joining the University, He was a research assistant professor at University of Missouri-Columbia, USA. He undertook postdoctoral research in molecular modeling and computational biophysics/biology at University of Missouri-Columbia. His research interests include molecular modeling, bioinformatics, computational biophysics/biology and their application to drug discovery. He actively develops novel docking algorithms and energy-scoring functions for protein–ligand interactions, protein–protein interactions, protein–RNA interactions, and modeling of quantitative structure-function relationships of therapeutically important proteins. His research has resulted in the publication of scientific software, book chapters and more than 70 peer-reviewed journal articles with more than 1300 citations from other scientists.

Academic Degrees

2003: Ph.D. degree in Computational Soft Matter Physics, Wuhan University;

1998: bachelor's degree in Material Physics, Wuhan University;

Professional Experience

2015-present : Professor, Huazhong University of Science and Technology;

2011-2015: Research Assistant Professor, University of Missouri-Columbia;

2008-2011: Research Associate, University of Missouri-Columbia;

2003-2008: Postdoctoral Researcher, University of Missouri-Columbia.

Selected Publications

1. Huang, S.-Y., Li, M., Wang, J., Pan, Y. Yi，HybridDock: A Hybrid Protein-Ligand Docking Protocol Integrating Protein- and Ligand-Based Approaches.，Journal of Chemical Information and Modeling，DOI:10.1021/acs.jcim, 2015。

2. Huang, S.-Y. Search strategies and evaluation in protein-protein docking: principles, advances and challenges. Drug Discovery Today, 20: 969-977，2015.

3. Huang, S.-Y., Zou, X. A knowledge-based scoring function for protein-RNA interactions derived from a statistical mechanics-based iterative method. Nucleic Acids Research, 42: e55, 2014.

4. Lensink, M.F., Moal, I.H., …, Huang, S.-Y., Zou, X., ... Blind prediction of interfacial water positions in CAPRI. Proteins, 82: 620-632, 2014.

5. Huang, S.-Y., Yan, C., Grinter, S.Z., Chang, S., Jiang, L., Zou X. Inclusion of the orientational entropic effect and low-resolution experimental information for protein-protein docking in Critical Assessment of PRedicted Interactions (CAPRI). Proteins, 81: 2183-2191, 2013.

6. Grinter, S.Z., Yan, C., Huang, S.-Y., Jiang, L., Zou, X. Automated Large-Scale File Preparation, Docking, and Scoring: Evaluation of ITScore and STScore Using the 2012 Community Structure-Activity Resource Benchmark. Journal of Chemical Information and Modeling, 53: 1905-1914, 2013.

7. Huang, S.-Y., Zou, X. ITScorePro – An efficient scoring program for evaluating the energy scores of protein structures. Methods in Molecular Biology (Clifton, NJ), 1137, 71-81 2013.

8. Moretti, R., Fleishman, S.J., …, Huang, S.-Y., Zou, X., ... Community‐wide evaluation of methods for predicting the effect of mutations on protein-protein interactions. Proteins, 81: 1980-1987, 2013.

9. Huang, S.-Y., Zou, X. A nonredundant structure dataset for benchmarking protein-RNA computational docking. Journal of Computational Chemistry, 34: 311-318, 2013.

10. Huang, S.-Y., Zou, X. Scoring and lessons learned with the CSAR benchmark using an improved iterative knowledge-based scoring function. Journal of Chemical Information and Modeling, 51: 2097-2106, 2011.

11. Huang, S.-Y., Zou, X. Construction and Test of Ligand Decoy Sets Using MDock: Community Structure Activity Resource Benchmarks for Binding Mode Prediction. Journal of Chemical Information and Modeling, 51: 2107-2114, 2011.

12. Fleishman, S. J., Whitehead, T. A., …, Huang, S.-Y., Zou, X., Wodak, S. J., Janin, J., Baker, D. Community-wide assessment of protein-interface modeling suggests improvements to design methodology. Journal of Molecular Biology, 414: 289-302, 2011.

13. Huang, S.-Y., Zou, X. Statistical mechanics-based method to extract atomic distance-dependent potentials from protein structures. Proteins: Structure Function, and Bioinformatics, 79: 2648-2661, 2011.

14. Rockey, W. M., Hernandez, F. J., Huang, S.-Y., Cao, S., et al. Rational truncation of an RNA aptamer to prostate-specific membrane antigen using computational structural modeling. Nucleic Acid Therapeutics, 21: 299-314, 2011.

15. Grinter, S. Z., Liang, Y., Huang, S.-Y., Hyder, S. M., Zou, X. An inverse docking approach for identifying new potential anti-cancer targets. Journal of Molecular Graphics and Modelling, 29:795-799, 2011.

16. Zhang, G., Huang, S.-Y., Yang, J., Shi, J., Yang, X., Moller, A., Zou, X., Cui, J. Ion sensing in the RCK1 domain of BK channels. Proceedings of National Academy of Sciences USA 107:18700-18705, 2010.

17. Huang, S.-Y., Zou, X. MDockPP: A hierarchical approach for protein-protein docking and its application to CAPRI rounds 15-19. Proteins: Structure Function, and Bioinformatics 78:3096-3103, 2010.

18. Huang, S.-Y., Zou, X. Inclusion of solvation and entropy in the knowledge-based scoring function for protein-ligand interactions. Journal of Chemical Information and Modeling 50:262-273, 2010.

19. Huang, S.-Y., Zou, X. Advances and challenges in protein-ligand docking. International Journal of Molecular Science 11:3016-3034, 2010.

20. Huang, S.-Y., Grinter, S.Z., Zou, X. Scoring functions and their evaluation methods for protein-ligand docking: recent advances and future directions. Physical Chemistry Chemical Physics 12:12899-908, 2010.

21. Yu T, Zou XQ, Huang SY, Zou XW, Cutoff variation induces different topological properties: a new discovery of amino acid network within protein, Journal of Theoretical Biology 256,408-413, 2009.

22. Huang, S.-Y., Bolser, D., Liu, H.-Y., Hwang, T.-C., Zou, X. Molecular modeling of the heterodimer of human CFTR

Selected Cases

Awards and Honors

• 2015 “1000 Young Talent Program” of P.R. China

• 2010 Natural Science's First Prize of Hubei Province (rank #4)

• 2005 National (Top 100) Excellent Doctoral Dissertation of P.R. China

• 2004 Provincial Excellent Doctoral Dissertation of Hubei of P. R. China

• 2002 National Academia Sinica Award of China

Courses Taught

• Thermal Physics