Yu Hao

Professor

Phone: 86-027-87543881

Email: hyu@hust.edu.cn

Academic Areas: Single molecule biophysics

Research Interests:

 

Academic Degrees

Professional Experience

Selected Publications

1.H Yu, MGW Siewny, DT Edwards, AW Sanders, and TT Perkins, Hidden dynamics in the unfolding of individual membrane proteins. Science, 355, 945-950 (2017).
2.K Neupane, DAN Foster, D Dee, H Yu, F Wang, MT Woodside, Direct observation of transition paths during the folding of proteins and nucleic acids. Science 532, 239-242 (2016).
3.H Yu, D Dee, X Liu, AM Brigley, I Sosova, MT Woodside, Protein misfolding occurs by slow diffusion across multiple barriers in a rough energy landscape. Proc. Natl. Acad. Sci. USA 112, 8308-8313 (2015).
4.H Yu, D Dee, MT Woodside, Single-molecule approaches to prion protein misfolding. Prion 7, 140-146 (2013).
5.H Yu, AN Gupta, X Liu, K Neupane, AM Brigley, I Sosova, MT Woodside, Energy landscape analysis of native folding of the prion protein yields the diffusion constant, transition path time, and rates. Proc. Natl. Acad. Sci. USA 109, 14452-14457 (2012).
6.K Neupane, DR Ritchie, H Yu, DAN Foster, F Wang, MT Woodside, Transition path times for nucleic acid folding determined from energy-landscape analysis of single-molecule trajectories. Phys. Rev. Lett. 109, 068102 (2012).
7.H Yu, X Liu, K Neupane, AN Gupta, AM Brigley, A Solanki, I Sosova, MT Woodside, Direct observation of multiple misfolding pathways in a single prion protein molecule. Proc. Natl. Acad. Sci. USA 109, 5283-5288 (2012).
8.AN Gupta, A Vincent, K Neupane, H Yu, F Wang, MT Woodside, Experimental validation of free-energy-landscape reconstruction from non-equilibrium single-molecule force spectroscopy measurements. Nature Physics 7, 631-634 (2011).
9.K Neupane, H Yu, DAN Foster, F Wang, MT Woodside, Single-molecule force spectroscopy of the add adenine riboswitch relates folding to regulatory mechanism. Nucleic Acids Research 39, 7677-7687 (2011)

Selected Cases

Awards and Honors

Courses Taught

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