Associate Professor

Phone: (027) 87558335-805

Email: cjchen@hust.edu.cn

Academic Areas: Computational biophysics

Research Interests: Molecular simulation, free energy calculation and protein folding dynamics

 

Dr. Chen Received his M.S. degree in Physics from Xuzhou Normal University, Xuzhou, China, in 2001 and his Ph.D. degree in Theoretical Physics from Huazhong University of Science and Technology, Wuhan, China, in 2007. From then till now, he is an Associate Professor in the School of Physics, Huazhong University of Science and Technology, Wuhan, China. His research interests are on the molecular simulation, free energy calculation and protein folding dynamics.

Academic Degrees

PhD in Theoretical Physics, 2007, Huazhong University of Science and Technology.

Professional Experience

2010-Present : Associate Professor, Huazhong University of Science and Technology;

2007-2010: Assistant Professor, Huazhong University of Science and Technology.

Selected Publications

[1] Chen, C., Y. Xiao, and Y. Huang, Improving the replica-exchange molecular-dynamics method for efficient sampling in the temperature space. Phys. Rev. E, 2015. 91: 052708.

[2] Chen, C., Y. Huang, W. Jiang, and Y. Xiao, A fast tomographic method for searching the minimum free energy path. J. Chem. Phys., 2014. 141: 154109.

[3] Chen, C., Y. Huang, X. Ji, and Y. Xiao, Efficiently finding the minimum free energy path from steepest descent path. J. Chem. Phys., 2013. 138: 164122.

[4] Chen, C., E. Wang, P. Liu, and Y. Xiao, Simulation study of the role of the ribosomal exit tunnel on protein folding. Phys. Rev. E, 2013. 87(2): 022701.

[5] Chen, C., Y. Huang, X. Jiang, and Y. Xiao, Binding free-energy calculation of an ion-peptide complex by constrained dynamics. Phys. Rev. E., 2013. 87: 062705.

[6] Chen, C., Y. Huang, and Y. Xiao, Free-energy calculations along a high-dimensional fragmented path with constrained dynamics. Phys. Rev. E., 2012. 86(3-1): 031901.

[7] Chen, C., Y. Huang, and Y. Xiao, Free Energy Calculation Methods of Biomolecules. Acta Biophys Sin, 2011. 27: 395-402.

[8] Chen, C. and Y. Xiao, Accurate free energy calculation along optimized paths. J. Comput. Chem., 2010. 31: 1368-1375.

[9] Chen, C. and Y. Xiao, Observation of multiple folding pathways of β-hairpin trpzip2 from independent continuous folding trajectories. Bioinformatics, 2008. 24: 659-665.

[10] Chen, C., L. Li, and Y. Xiao, All-atom contact potential approach to protein thermostability analysis. Biopolymers, 2007. 85(1): 28-37.

[11] Chen, C. and Y. Xiao, Molecular dynamics simulations of folding processes of a beta-hairpin in an implicit solvent. Phys. Biol., 2006. 3: 161-171.

[12] Chen, C., L. Li, and Y. Xiao, Identification of key residues in proteins by using their physical characters. Physical Review E, 2006. 73(4).

[13] Chen, C., Y. Xiao, and L. Zhang, A Directed Essential Dynamics Simulation of Peptide Folding. Biophys. J., 2005. 88: 3276-3285.

Awards and Honors

• National Natural Science Foundation of China , Grant No. 30800166;

• National Natural Science Foundation of China , Grant No. 31370848;

Courses Taught

• Theoretical Mechanics;

• Computational Physics;

• Molecular Simulation

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